\n @ARTICLE{Schalk2018,
\n author = {Schalk, Stefan G. AND Huang, Jing AND Li, Jia AND Demi, Libertario AND Wijkstra, Hessel AND Huang, Pintong AND Mischi, Massimo},
\n title = {3-D Quantitative Dynamic Contrast Ultrasound for Prostate Cancer Localization},
\n abstract = {To investigate quantitative 3-D dynamic contrast-enhanced ultrasound (DCE-US) and, in particular 3-D contrast-ultrasound dispersion imaging (CUDI), for prostate cancer detection and localization, 43 patients referred for 10ā€“12-core systematic biopsy underwent 3-D DCE-US. For each 3-D DCE-US recording, parametric maps of CUDI-based and perfusion-based parameters were computed. The parametric maps were divided in regions, each corresponding to a biopsy core. The obtained parameters were validated per biopsy location and after combining two or more adjacent regions. For CUDI by correlation (r) and for the wash-in time (WIT), a significant difference in parameter values between benign and malignant biopsy cores was found (pā€‰<ā€‰0.001). In a per-prostate analysis, sensitivity and specificity were 94% and 50% for r, and 53% and 81% for WIT. Based on these results, it can be concluded that quantitative 3-D DCE-US could aid in localizing prostate cancer. Therefore, we recommend follow-up studies to investigate its value for targeting biopsies.},
\n keywords = {},
\n pages = {807-814},
\n bookTitle = {Ultrasound in Medicine