\n @ARTICLE{deLepper2017,
\n author = {de Lepper, Anouk G.W. AND Herold, Ingeborg H.F. AND Saporito, Salvatore AND Bouwman, R. Arthur AND Mischi, Massimo AND Korsten, Hendrikus H.M. AND Reesink, Koen D. AND Houthuizen, Patrick},
\n title = {Noninvasive pulmonary transit time: A new parameter for general cardiac performance},
\n abstract = {Introduction: Pulmonary transit time (PTT) assessed with contrast-enhanced ultrasound (CEUS) is a novel tool to evaluate cardiac function. PTT represents the time for a bolus of contrast to pass from the right to the left ventricle, measured according to the indicator dilution principles using CEUS. We investigated the hypothesis that PTT is a measure of general cardiac performance in patient populations eligible for cardiac resynchronization therapy (CRT).\nMethods: The study population consisted of heart failure patients referred for CRT with NYHA class II–IV, left ventricular ejection fraction (LVEF)≤35% and QRS≥120 ms. CEUS, ECG, and blood were analyzed, and participants completed a quality of life questionnaire at baseline and 3 months after CRT implantation. Normalized PTT (nPTT) was calculated to compensate for the heart rate. Correlations were assessed with Pearson’s or Spearman’s coefficients and stratified for rhythm and NYHA class.\nResults: The study population consisted of 94 patients (67 men) with a mean age of 70±8.9 years. (n)PTT was significantly correlated with left ventricular parameters (rs=−.487, P<.001), right ventricular parameters (r=−.282, P=.004), N-terminal pro-B-type natriuretic peptide (NT-proBNP) (rs=.475, P<.001), and quality of life (rs=.364, P<.001). Stronger significant correlations were found in patients in sinus rhythm.\nConclusion: CEUS-derived PTT and nPTT correlate to a fair degree with measures of systolic and diastolic function, NT-pro-BNP, and quality of life. As CEUS-derived PTT can be obtained easily, noninvasively and at the bedside, it is a promising future measure of general cardiac performance.},
\n keywords = {contrast echocardiography, diastolic dysfunction, heart failure, left ventricular function, right ventricular function, systolic function, pulmonary transit time},
\n pages = {1138-1145},
\n bookTitle = {Echocardiograph},
\n volume = {34},
number = {8},
year = {2017},
month = {Jun.}