\n @ARTICLE{vanSloun2017,
\n author = {van Sloun, Ruud JG AND Demi, Libertario AND Postema, Arnoud W AND de la Rosette, Jean JMCH AND Wijkstra, Hessel AND Mischi, Massimo},
\n title = {Ultrasound-contrast-agent dispersion and velocity imaging for prostate cancer localization},
\n abstract = {Prostate cancer (PCa) is the second-leading cause of cancer death in men; however, reliable tools for de- tection and localization are still lacking. Dynamic Contrast Enhanced UltraSound (DCE-US) is a diagnostic tool that is suitable for analysis of vascularization, by imaging an intravenously injected microbubble bo- lus. The localization of angiogenic vascularization associated with the development of tumors is of par- ticular interest. Recently, methods for the analysis of the bolus convective dispersion process have shown promise to localize angiogenesis. However, independent estimation of dispersion was not possible due to the ambiguity between convection and dispersion. Therefore, in this study we propose a new method that considers the vascular network as a dynamic linear system, whose impulse response can be locally identified. To this end, model-based parameter estimation is employed, that permits extraction of the apparent dispersion coefficient ( D ), velocity ( v ), and Péclet number (Pe) of the system. Clinical evalua- tion using data recorded from 25 patients shows that the proposed method can be applied effectively to DCE-US, and is able to locally characterize the hemodynamics, yielding promising results (receiver- operating-characteristic curve area of 0.84) for prostate cancer localization.},
\n keywords = {},
\n pages = {610–619},
\n bookTitle = {Medical Image Analysis},
\n volume = {35},
year = {2017},
month = {Jan.}
}