\n @INPROCEEDINGS{Wildeboer2017a,
\n author = {Wildeboer, R.R. AND van Sloun, R.J.G. AND Schalk, S.G. AND Mannaerts, C.K. AND van der Linden, J.C. AND Huang, P. AND Wijkstra, H. AND Mischi, M.},
\n title = {Three-dimensional estimation of ultrasound-contrast-agent dispersion and convection in the prostate},
\n abstract = {Prostate cancer (PCa) diagnosis still relies on systematic biopsy due to the insufficient reliability of imaging techniques. In this work, we introduce a new method to quantify contrast agent convective dispersion (D) and velocity (v) in a three-dimensional dynamic contrast-enhanced ultrasound (3D DCE-US) recording. First, the concentration gradients of the data are established using Gaussian derivatives in space and time. Assuming D and v to be locally constant, the convective-dispersion equation can then be solved by minimizing a leastsquares problem within a moving 3D kernel. Six PCa patients underwent two-minute 3D DCE-US examination prior to radical prostatectomy. Subsequently, the 3D parametric maps of D and v were compared with the 3D histopathologic data. Preliminary results suggest a good correlation between malignancy according to histopathology and both D and v maps.},
\n keywords = {},
\n pages = {1-4},
\n bookTitle = {2017 IEEE International Ultrasonics Symposium (IUS)},
\n year = {2017},
month = {Sep.}